Bromin derivative of fatty acids.



UNITED STATES PATENT OFFICE.

EMIL FISCHER, OF BERLIN, GERMANY, ASSIGNOR TO FARBENFABRIKEN VORM FRIEDR. BAYER & 00., or ELBERFELD, GERMANY, A CORPORA- TIQN OFIGEBMANY.

snomm DERIVATIVE OF FATTY ACIDS.

Patented s in 9, 1907.

Original application f lled June 23, @1906, Serial No. 823,037. Divided and this application filed December 5, 1906. Serial No. 346,461.

To all whom it may concern:

Be it known that I, EMIL FISCHER, professor of chemistry, a citizen of the German Empire, residing .at Berlin, Kingdom of Prussia, have invented new and useful Improvements in Bromin Derivatives of Fatty fields, of which the following is. a specifica- The present application, which is a divisional application from my application, Se-- rial No. 323,037, filed June 23, 1906, relates specifically to magnesium salts of the monobromin derivatives of high-molecular fatty acids and the production thereof.

I have found that the magnesium salts of monobromin substituted high molecular fatty acidssuch as monobromobehenic acid, monobromostearic acid, or the likep0ssess valuable thera eutic properties. These salts, which are soli substances, have no taste and are valuable substitutes for potassium bromid an average dose being'from one to four grams.

My new pre arations areobtained by converting the ee monobromin substituted high-molecular fatty acids or their alkaline salts into their magnesium salts. The monobromin substituted high molecular fatty acids are repared by treating With hydrogen.

bromid t e high-molecular acids of the oleic series, such'as oleic acid, erucic acid, brassidic acid, elaidic acid, or the like.

. The preparation of the magnesium salts of the bromin derivatives of-the high-molecular fatty acids-must be carried out in such a manner that the resulting salts are neutral, because salts containing free acid have a faint odor and taste. Under the terms higher fatty acids and high-molecular fatty acids those acids are generally understood which contain more than'about twelve carbon atoms in their molecule.

The preparation of the magnesium salt of monobromo'behenic acid, which is obtained by treating erucic acid with hydrogen bromid, is carried out as follows, the parts being by weight.

Example 1 :Twenty-seven parts of crystallized magnesium chlorid containing water of crystallization and fifteen parts of ammonium chlorid are dissolved in fifty-five parts of hot water. The solution is saturated with gaseous ammonia, the reci itate thus obtaincd is filtered off, an the ltcred solution is mixed with four hundred parts of methylic alcohol. To the liquid thus obtained a solution of forty parts 'of bromobchenic acid in four hundred slowly added uring stirring. The precipitated magnesium salt is filtered off, washed with meth lic alcohol, water, and again with meth lic a cohol, and dried in vacuo, It is a color ess and tasteless oWder. It is formed according to the followmg equation:

Example 2: The same salt results by the interaction of alkaline salts of broinobehenic acid with magnesium chlorid in the following manner: Monobromobehenic acid is dissolved in a somewhat larger quantity of caustic pot-- ash than is required by the acid by shaking it at ordinary temperature with highly-diluted caustic potash, (about 1/50 normal.) calculated quantity of a dilute aqueous solution of chlorid of magnesium is added 'to the solution, and it is stirred until the flocculent colorless precipitate has settled. It is filtered off with suction, washed with water, then with alcohol to remove small quantities of free bromobehenic acid which may be present, and dried in vacuo. This purification is not necessary if an aqueous solution of chlorid of magnesium mixed with an excess of ammonia be used. The preci itated magnesium salt of bromobehenic aci is neutral and forms, after being washed with water and (C,.Il O Br) l\*lg obtained from he corresponding high-molecular acids of ihe oleic series, which are solid, stable l c-lies, tasteless, colorless and lnsoluarts of methylic alcohol is' The ble in water, substantially as hcreinbefore described.

2. The herein-described magnesium saltlof monobromobehenic acid, (O fL BrOg lllg, obtained from monobromobehenic acid, which is a solid, stable body, tasteless, colorless and insoluble in water, substantially as heyeinbefore described.

EMIL Witnesses HENRY HASPER, WOLDEMAR HAUPT. 

